The LRSM, through the NSF-supported Penn MRSEC, is continuing a series of Science Cafés that began last year to promote NOVA’s four part TV series on materials, ‘Making Stuff with David Pogue,’ on public television. The Science Cafés, which are science talks for laymen about materials-related topic of current interest, will take place at 7:30 pm at Stoney’s British Pub, 3007 Concord Pike, Wilmington DE and Saint Declan's Well, 3131 Walnut St. Philadelphia, PA, at 6:00 pm.
These programs are free and anyone who is interested is invited to attend. No purchase is necessary.
For further information contact:
Andrew R. McGhie at
|LIST OF TALKS|
|September 8, 2014
Stoney’s British Pub
|Eric L. Hume, MD
Perelman SOM, University of Pennsylvania
“Adventures and Misadventures in Materials and Biology: 50 Years of Hip Replacement Progress”
Hip replacement is a spectacularly successful operation to relieve pain from hip arthritis. Replacement offers high success rates and very good pain control, and allows high levels of recreation and work activity. It is a gold standard for successful surgical treatment. The development history is an interesting story of intuition, engineering methodology, materials development and selection, and biology. As most stories go, replacement was born from the mind of a visionary, steadily progressed with careful consideration of failures, took surprising leaps forward, but also saw catastrophes resulting from well-considered new concepts. We will start at the beginning, touch on some of the more interesting and important of these chapters, and end with where we are now and where I think we need to go.
|September 3, 2014
Saint Declan's Well
Matthew J. Lazzara
Over the last decade, an improved ability to sequence tumor DNA has been leveraged to identify genetic mutations that promote tumorigenesis and resistance to therapy. In an increasing number of cancer settings, sequencing individual patient DNA now allows for the optimization of therapeutic regimens by including drugs that target specific mutant proteins. This talk will highlight several examples of the successful application of this personalized medicine approach as well as examples of tumor adaptation to outsmart even the best available personalized approaches. The talk will also cover computational modeling approaches being developed by engineers to gain quantitative and predictive understanding of the biochemical processes that dictate cancer cell response to therapy.