@article{azarjbo2007,
author = {Azar, F S and Lee, K and Khamene, A and Choe, R and Corlu, A and
Konecky S D and Sauer, F and Yodh, A G},
title = {Standardized platform for coregistration of nonconcurrent diffuse
optical and magnetic resonance breast images obtained in different
geometries},
journal = {J Biomed Opt},
year = {2007},
volume = {12},
pages = {051902},
number = {5},
month = {Oct-Sept},
doi = {10.1117/1.2798630},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/azarjbo2007.pdf}
}
@article{BednovUCY04,
author = {Bednov, A. and Ulyanov, S. and Cheung, C. and Yodh, A. G.},
title = {Correlation properties of multiple scattered light: implication to
coherent diagnostics of burned skin},
journal = {Journal of Biomedical Optics},
year = {2004},
volume = {9},
pages = {347-352},
doi = {10.1117/1.1646171},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/CecilCheung/burnedskinArjunJBO2004.pdf}
}
@article{BoasPRL,
author = {Boas, D. A. and Campbell, L. E. and Yodh, A. G.},
title = {Scattering and Imaging with Diffusing Temporal Field Correlations},
journal = {Physical Review Letters},
year = {1995},
volume = {75},
pages = {1855-1858},
number = {9},
doi = {10.1103/PhysRevLett.75.1855},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/boas1995-PRL.pdf}
}
@article{BoasPNAS1994,
author = {Boas, D. A. and Oleary, M. A. and Chance, B. and Yodh, A. G.},
title = {Scattering of Diffuse Photon Density Waves by Spherical Inhomogeneities
within Turbid Media - Analytic Solution and Applications},
journal = {Proc. Natl. Acad. Sci. USA},
year = {1994},
volume = {91},
pages = {4887-4891},
number = {11},
doi = {10.1073/pnas.91.11.4887},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/boas1994procnatlacad91.pdf}
}
@article{BoasPRE1993,
author = {Boas, D. A. and Oleary, M. A. and Chance, B. and Yodh, A. G.},
title = {Scattering and Wavelength Transduction of Diffuse Photon Density
Waves},
journal = {Phys. Rev. E},
year = {1993},
volume = {47},
pages = {R2999-R3002},
number = {5},
doi = {10.1103/PhysRevE.47.R2999},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/boas1993-phy-rev-e.pdf}
}
@article{boascorrelationjosa,
author = {Boas, D. A. and Yodh, A. G.},
title = {Spatially varying dynamical properties of turbid media probed with
diffusing temporal light correlation},
journal = {J. Opt. Soc. Am. {A}},
year = {1997},
volume = {14},
pages = {192-215},
number = {1},
doi = {10.1364/JOSAA.14.000192},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/boas1997joptsocama14.pdf}
}
@article{BoasAO,
author = {Boas, D.A. and O'Leary, M.A. and Chance, B. and Yodh, A.G.},
title = {Detection and characterization of optical inhomogeneities with diffuse
photon density waves: a signal-to-noise analysis},
journal = {Applied Optics},
year = {1997},
volume = {36},
pages = {75-92},
doi = {10.1364/AO.36.000075},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/boas1997appopt36.pdf}
}
@article{Buckley09OptExp17,
author = {Erin M. Buckley and Noah M. Cook and Turgut Durduran and Meeri N.
Kim and Chao Zhou and Regine Choe and Guoqiang Yu and Susan Schultz
and Chandra M. Sehgal and Daniel J. Licht and Peter H. Arger and
Mary E. Putt and Hallam H. Hurt and Arjun G. Yodh},
title = {Cerebral hemodynamics in preterm infants during positional intervention
measured with diffuse correlation spectroscopy and transcranial Doppler
ultrasound},
journal = {Opt. Express},
year = {2009},
volume = {17},
pages = {12571--12581},
number = {15},
doi = {10.1364/OE.17.012571},
publisher = {OSA},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/buckley2009-optexp17-cerebral-hemodynamics-in-preterm-infants.pdf}
}
@article{busch:1840,
author = {David R. Busch and Wensheng Guo and Regine Choe and Turgut Durduran
and Michael D. Feldman and Carolyn Mies and Mark A. Rosen and Mitchell
D. Schnall and Brian J. Czerniecki and Julia Tchou and Angela DeMichele
and Mary E. Putt and Arjun G. Yodh},
title = {Computer aided automatic detection of malignant lesions in diffuse
optical mammography},
journal = {Medical Physics},
year = {2010},
volume = {37},
pages = {1840-1849},
number = {4},
month = {April},
doi = {10.1118/1.3314075},
keywords = {biological tissues; biomedical optical imaging; cancer; mammography;
optical tomography},
publisher = {AAPM},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2010/busch2010-computer-aided-automatic.pdf}
}
@article{b9pp00004f,
author = {Theresa M. Busch and Xiaoman Xing and Guoqiang Yu and Arjun Yodh
and E. Paul Wileyto and Hsing-Wen Wang and Turgut Durduran and Timothy
C. Zhu and Ken Kang-Hsin Wang},
title = {Fluence rate-dependent intratumor heterogeneity in physiologic and
cytotoxic responses to Photofrin photodynamic therapy},
journal = {Photochemical \& Photobiological Sciences},
year = {2009},
volume = {8},
pages = {1683--1693},
number = {12},
month = {August},
abstract = {Photodynamic therapy (PDT) can lead to the creation of heterogeneous,
response-limiting hypoxia during illumination, which may be controlled
in part through illumination fluence rate. In the present report
we consider (1) regional differences in hypoxia, vascular response,
and cell kill as a function of tumor depth and (2) the role of fluence
rate as a mediator of depth-dependent regional intratumor heterogeneity.
Intradermal RIF murine tumors were treated with Photofrin PDT using
surface illumination at an irradiance of 75 or 38 mW cm-2. Regional
heterogeneity in tumor response was examined through comparison of
effects in the surface vs. base of tumors, i.e. along a plane parallel
to the skin surface and perpendicular to the incident illumination.
75 mW cm-2 PDT created significantly greater hypoxia in tumor bases
relative to their surfaces. Increased hypoxia in the tumor base could
not be attributed to regional differences in Photofrin concentration
nor effects of fluence rate distribution on photochemical oxygen
consumption, but significant depth-dependent heterogeneity in vascular
responses and cytotoxic response were detected. At a lower fluence
rate of 38 mW cm-2, no detectable regional differences in hypoxia
or cytotoxic responses were apparent, and heterogeneity in vascular
response was significantly less than that during 75 mW cm-2 PDT.
This research suggests that the benefits of low-fluence-rate PDT
are mediated in part by a reduction in intratumor heterogeneity in
hypoxic, vascular and cytotoxic responses.},
doi = {10.1039/b9pp00004f},
timestamp = {2010.01.25},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2009/Photochem_Photobiol_Sci_v8_1683_2009.pdf}
}
@article{chaojbo2007,
author = {Zhou C and Choe R and Shah, N and Durduran, T and Yu, Guoqiang and
Durkin, A and Hsiang, D and Mehta, R and Butler, J and Cerussi, A
and Tromberg, B J and Yodh, A G},
title = {Diffuse optical monitoring of blood flow and oxygenation in human
breast cancer during early stages of neoadjuvant chemotherapy},
journal = {J Biomed Opt},
year = {2007},
volume = {12},
pages = {051903},
number = {5},
month = {Oct-Sept},
doi = {10.1364/OE.15.015507},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/zhoujbo2007.pdf}
}
@article{10.1371/journal.pone.0006539,
author = {Cerniglia, George J. AND Pore, Nabendu AND Tsai, Jeff H. AND Schultz,
Susan AND Mick, Rosemarie AND Choe, Regine AND Xing, Xiaoman AND
Durduran, Turgut AND Yodh, Arjun G. AND Evans, Sydney M. AND Koch,
Cameron J. AND Hahn, Stephen M. AND Quon, Harry AND Sehgal, Chandra
M. AND Lee, William M. F. AND Maity, Amit},
title = {Epidermal Growth Factor Receptor Inhibition Modulates the Microenvironment
by Vascular Normalization to Improve Chemotherapy and Radiotherapy
Efficacy},
journal = {PLoS ONE},
year = {2009},
volume = {4},
pages = {e6539},
number = {8},
month = {08},
abstract = { Background Epidermal growth factor receptor
(EGFR) inhibitors have shown only modest clinical activity when used
as single agents to treat cancers. They decrease tumor cell expression
of hypoxia-inducible factor 1-α (HIF-1α) and vascular endothelial
growth factor (VEGF). Hypothesizing that this might normalize tumor
vasculature, we examined the effects of the EGFR inhibitor erlotinib
on tumor vascular function, tumor microenvironment (TME) and chemotherapy
and radiotherapy sensitivity.
Methodology/Principal
Findings Erlotinib treatment of human tumor cells in
vitro and mice bearing xenografts in vivo
led to decreased HIF-1α and VEGF expression. Treatment altered xenograft
vessel morphology assessed by confocal microscopy (following tomato
lectin injection) and decreased vessel permeability (measured by
Evan's blue extravasation), suggesting vascular normalization. Erlotinib
increased tumor blood flow measured by Power Doppler ultrasound and
decreased hypoxia measured by EF5 immunohistochemistry and tumor
O2 saturation measured by optical spectroscopy. Predicting
that these changes would improve drug delivery and increase response
to chemotherapy and radiation, we performed tumor regrowth studies
in nude mice with xenografts treated with erlotinib and either radiotherapy
or the chemotherapeutic agent cisplatin. Erlotinib therapy followed
by cisplatin led to synergistic inhibition of tumor growth compared
with either treatment by itself (p<0.001). Treatment with erlotinib
before cisplatin led to greater tumor growth inhibition than did
treatment with cisplatin before erlotinib (p = 0.006). Erlotinib
followed by radiation inhibited tumor regrowth to a greater degree
than did radiation alone, although the interaction between erlotinib
and radiation was not synergistic.
Conclusions/Significance
EGFR inhibitors have shown clinical benefit when used in combination
with conventional cytotoxic therapy. Our studies show that targeting
tumor cells with EGFR inhibitors may modulate the TME via vascular
normalization to increase response to chemotherapy and radiotherapy.
These studies suggest ways to assess the response of tumors to EGFR
inhibition using non-invasive imaging of the TME.
},
doi = {10.1371/journal.pone.0006539},
publisher = {Public Library of Science},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/2009/GJCerniglia2009PLOS1v4.pdf}
}
@article{CheungCTGY01,
author = {Cheung, C. and Culver, J. P. and Takahashi, K. and Greenberg, J.
H. and Yodh, A. G.},
title = {In vivo cerebrovascular measurement combining diffuse near-infrared
absorption and correlation spectroscopies},
journal = {Physics In Medicine And Biology},
year = {2001},
volume = {46},
pages = {2053-2065},
doi = {10.1088/0031-9155/46/8/302},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/CecilCheung/cheung2001.pdf}
}
@article{CheungSBDPHY03,
author = {Cheung, R. and Solonenko, M. and Busch, T. M. and Del Piero, F. and
Putt, M. E. and Hahn, S. M. and Yodh, A. G.},
title = {Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced
depth of necrosis in a murine tumor model},
journal = {Journal Of Biomedical Optics},
year = {2003},
volume = {8},
pages = {248-252},
doi = {10.1117/1.1560011},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/PDTrelated/RCheung2003JBOv8i2.pdf}
}
@article{ChoeCLDKGACFDCRY05,
author = {Choe, R. and Corlu, A. and Lee, K. and Durduran, T. and Konecky,
S. D. and Grosicka-Koptyra, M. and Arridge, S. R. and Czerniecki,
B. J. and Fraker, D. L. and DeMichele, A. and Chance, B. and Rosen,
M. A. and Yodh, A. G.},
title = {Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy:
A case study with comparison to MRI},
journal = {Med. Phys.},
year = {2005},
volume = {32},
pages = {1128-1139},
doi = {10.1118/1.1869612},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/RegineChoe/RChoeMP2005v32.pdf}
}
@article{ChoeDYNCYR03,
author = {Choe, R. and Durduran, T. and Yu, G. Q. and Nijland, M. J. M. and
Chance, B. and Yodh, A. G. and Ramanujam, N.},
title = {Transabdominal near infrared oximetry of hypoxic stress in fetal
sheep brain in utero},
journal = {Proceedings Of The National Academy Of Sciences Of The United States
Of America},
year = {2003},
volume = {100},
pages = {12950-12954},
doi = {10.1073/pnas.1735462100},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/RegineChoe/RChoe2003PNASv100i22.pdf}
}
@article{choe2009-jbiomedopt,
author = {Regine Choe and Soren D. Konecky and Alper Corlu and Kijoon Lee and
Turgut Durduran and David R. Busch and Saurav Pathak and Brian J.
Czerniecki and Julia Tchou and Douglas L. Fraker and Angela DeMichele
and Britton Chance and Simon R. Arridge and Martin Schweiger and
Joseph P. Culver and Mitchell D. Schnall and Mary E. Putt and Mark
A. Rosen and Arjun G. Yodh},
title = {Differentiation of benign and malignant breast tumors by in-vivo
three-dimensional parallel-plate diffuse optical tomography},
journal = {Journal of Biomedical Optics},
year = {2009},
volume = {14},
pages = {024020},
number = {2},
month = {April},
eid = {024020},
doi = {10.1117/1.3103325},
numpages = {18},
publisher = {SPIE},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/choe2009-jbiomedopt.pdf}
}
@incollection{RChoeBookchapterETBIMc18,
author = {Choe, R and Yodh, A G},
title = {Diffuse Optical Tomography of the Breast},
booktitle = {Emerging Technologies in Breast Imaging and Mammography},
publisher = {American Scientific Publishers},
year = {2008},
editor = {Suri, J and Rangayyan, R M and Laxminarayan, S},
chapter = {18},
pages = {317-342},
address = {Stevenson Ranch, CA},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/BookChapterColorScanRC.pdf}
}
@article{sochung2011_jioh,
author = {Chung, S. H. and Mehta, R. and Tromberg, B. J. and Yodh, A. G.},
title = {Non-invasive measurement of deep tissue temperature changes caused
by apoptosis during breast cancer neoadjuvant chemotherapy: A case
study},
journal = {Journal of Innovative Optical Health Sciences},
year = {2011},
volume = {4},
pages = {361-372 },
doi = {10.1142/S1793545811001708},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2011/sochung2011_JIOHS_04_4_pp361.pdf}
}
@article{CorluCDLSHAY05,
author = {Corlu, A. and Choe, R. and Durduran, T. and Lee, K. and Schweiger,
M. and Hillman, E. M. C. and Arridge, S. R. and Yodh, A. G.},
title = {Diffuse optical tomography with spectral constraints and wavelength
optimization},
journal = {Applied Optics},
year = {2005},
volume = {44},
pages = {2082-2093},
doi = {10.1364/AO.44.002082},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/AlperCorlu/ACorlu2005AOv44i11.pdf}
}
@article{fluorescenceBreast,
author = {Corlu, A and Choe, R and Durduran, T and Rosen, M A and Schweiger,
M and Arridge, S R and Yodh, A G},
title = {Three-dimensional \textit{in vivo} fluorescence diffuse optical tomography
of breast cancer in humans},
journal = {Opt. Express},
year = {2007},
volume = {15},
pages = {6696-6716},
number = {11},
doi = {10.1364/OE.15.006696},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/AlperCorlu/corlufluorescencebreast2007.pdf}
}
@article{CorluDCSHAY03,
author = {Corlu, A. and Durduran, T. and Choe, R. and Schweiger, M. and Hillman,
E. M. C. and Arridge, S. R. and Yodh, A. G.},
title = {Uniqueness and wavelength optimization in continuous-wave multispectral
diffuse optical tomography},
journal = {Optics Letters},
year = {2003},
volume = {28},
pages = {2339-2341},
doi = {10.1364/OL.28.002339},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/AlperCorlu/ACorlu2003OLv28i23.pdf}
}
@article{CulverCHZDSNCY03,
author = {Culver, J. P. and Choe, R. and Holboke, M. J. and Zubkov, L. and
Durduran, T. and Slemp, A. and Ntziachristos, V. and Chance, B. and
Yodh, A. G.},
title = {Three-dimensional diffuse optical tomography in the parallel plane
transmission geometry: Evaluation of a hybrid frequency domain/continuous
wave clinical system for breast imaging},
journal = {Medical Physics},
year = {2003},
volume = {30},
pages = {235-247},
doi = {10.1118/1.1534109},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/JoeCulver/CulverMedPhys2003.pdf}
}
@article{CulverDCFGY03,
author = {Culver, J. P. and Durduran, T. and Cheung, C. and Furuya, D. and
Greenberg, J. H. and Yodh, A. G.},
title = {Diffuse optical measurement of hemoglobin and cerebral blood flow
in rat brain during hypercapnia, hypoxia and cardiac arrest},
journal = {Oxygen Transport To Tissue Volume Xxiii},
year = {2003},
volume = {510},
pages = {293-297},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/JoeCulver/JPCulver2001isott.pdf}
}
@article{CulverDFCGY03,
author = {Culver, J. P. and Durduran, T. and Furuya, T. and Cheung, C. and
Greenberg, J. H. and Yodh, A. G.},
title = {Diffuse optical tomography of cerebral blood flow, oxygenation, and
metabolism in rat during focal ischemia},
journal = {Journal Of Cerebral Blood Flow And Metabolism},
year = {2003},
volume = {23},
pages = {911-924},
doi = {10.1097/01.WCB.0000076703.71231.BB},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/JoeCulver/JPCulver2003JCBFM.pdf}
}
@article{CulverNHY01,
author = {Culver, J. P. and Ntziachristos, V. and Holboke, M. J. and Yodh,
A. G.},
title = {Optimization of optode arrangements for diffuse optical tomography:
A singular-value analysis},
journal = {Optics Letters},
year = {2001},
volume = {26},
pages = {701-703},
doi = {10.1364/OL.26.000701},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/JoeCulver/JPCulverOL2001v26i10.pdf}
}
@article{DanenWLTY98,
author = {Danen, R. M. and Wang, Y. and Li, X. D. and Thayer, W. S. and Yodh,
A. G.},
title = {Regional imager for low-resolution functional imaging of the brain
with diffusing near-infrared light},
journal = {Photochemistry And Photobiology},
year = {1998},
volume = {67},
pages = {33-40},
doi = {10.1111/j.1751-1097.1998.tb05162.x},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/danen1998-photochem-photobio.pdf}
}
@article{Du:2006:Lasers-Surg-Med:16788929,
author = {Du, K L and Mick, R and Busch, T M and Zhu, T C and Finlay, J C and
Yu, G and Yodh, A G and Malkowicz, S B and Smith, D and Whittington,
R and Stripp, D and Hahn, S M},
title = {Preliminary results of interstitial motexafin lutetium-mediated PDT
for prostate cancer},
journal = {Lasers Surg Med},
year = {2006},
volume = {38},
pages = {427-434},
number = {5},
month = {Jun},
abstract = {BACKGROUND AND OBJECTIVES: Interstitial photodynamic therapy (PDT)
is an emerging modality for the treatment of solid organ disease.
Our group at the University of Pennsylvania has performed extensive
studies that demonstrate the feasibility of interstitial PDT for
prostate cancer. Our preclinical and clinical experience is herein
detailed. STUDY DESIGN/MATERIALS AND METHODS: We have treated 16
canines in preclinical studies, and 16 human subjects in a Phase
I study, using motexafin lutetium-mediated PDT for recurrent prostate
adenocarcinoma. Dosimetry of light fluence, drug level and oxygen
distribution for these patients were performed. RESULTS: We demonstrate
the safe and comprehensive treatment of the prostate using PDT. However,
there is significant variability in the dose distribution and the
subsequent tissue necrosis throughout the prostate. CONCLUSIONS:
PDT is an attractive option for the treatment of prostate adenocarcinoma.
However, the observed variation in PDT dose distribution translates
into uncertain therapeutic reproducibility. Our future focus will
be on the development of an integrated system that is able to both
detect and compensate for dose variations in real-time, in order
to deliver a consistent overall PDT dose distribution.},
doi = {10.1002/lsm.20341},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/GuoqingYu/Du:2006:Lasers-Surg-Med:16788929.pdf}
}
@article{DurduranThesisAbstMedPhys04,
author = {Durduran, T.},
title = {Noninvasive measurements of tissue hemodynamics with hybrid diffuse
optical methods},
journal = { Medical Physics},
year = {2004},
volume = {31},
pages = {2178},
doi = {10.1118/1.1763412},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/TurgutDurduran/turgutThesisAbstract.pdf}
}
@article{DurduranBYZFYDG04,
author = {Durduran, T. and Burnett, M. G. and Yu, G. and Zhou, C. and Furuya,
D. and Yodh, A. G. and Detre, J. A. and Greenberg, J. H.},
title = {Spatiotemporal Quantification of Cerebral Blood Flow During Functional
Activation in Rat Somatosensory Cortex Using Laser-Speckle Flowmetry},
journal = {Journal of Cerebral Blood Flow \& Metabolism},
year = {2004},
volume = {24},
pages = {518-525},
doi = {10.1097/00004647-200405000-00005},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/TurgutDurduran/jcbfm2004durduranspeckle.pdf}
}
@article{durduran2010-rpp73-dotmt,
author = {T Durduran and R Choe and W B Baker and A G Yodh},
title = {Diffuse optics for tissue monitoring and tomography},
journal = {Reports on Progress in Physics},
year = {2010},
volume = {73},
pages = {076701},
number = {7},
month = {June},
abstract = {This review describes the diffusion model for light transport in tissues
and the medical applications of diffuse light. Diffuse optics is
particularly useful for measurement of tissue hemodynamics, wherein
quantitative assessment of oxy- and deoxy-hemoglobin concentrations
and blood flow are desired. The theoretical basis for near-infrared
or diffuse optical spectroscopy is developed, and the basic elements
of diffuse optical tomography are outlined. We also discuss diffuse
correlation spectroscopy, a technique whereby temporal correlation
functions of diffusing light are transported through tissue and are
used to measure blood flow. Essential instrumentation is described,
and representative brain and breast functional imaging and monitoring
results illustrate the workings of these new tissue diagnostics.},
doi = {10.1088/0034-4885/73/7/076701},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2010/durduran2010-rpp73-dotmt.pdf}
}
@article{DurduranCCZHGCY02,
author = {Durduran, T. and Choe, R. and Culver, J. P. and Zubkov, L. and Holboke,
M. J. and Giammarco, J. and Chance, B. and Yodh, A. G.},
title = {Bulk optical properties of healthy female breast tissue},
journal = {Physics In Medicine And Biology},
year = {2002},
volume = {47},
pages = {2847-2861},
doi = {10.1088/0031-9155/47/16/302},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/TurgutDurduran/TDurduran2002PMB47.pdf}
}
@article{DurduranYZWPSSGYB05,
author = {Durduran, T. and Choe, R. and Yu, G. Q. and Zhou, C. and Tchou, J.
C. and Czerniecki, B. J. and Yodh, A. G.},
title = {Diffuse optical measurement of blood flow in breast tumors},
journal = {Optics Letters},
year = {2005},
volume = {30},
pages = {2915-2917},
doi = {10.1364/OL.30.002915},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/TurgutDurduran/TurgutBreastFlowOL05.pdf}
}
@article{DurduranCHLZCPY99,
author = {Durduran, T. and Culver, J. P. and Holboke, M. J. and Li, X. D. and
Zubkov, L. and Chance, B. and Pattanayak, D. N. and Yodh, A. G.},
title = {Algorithms for 3D localization and imaging using near-field diffraction
tomography with diffuse light},
journal = {Optics Express},
year = {1999},
volume = {4},
pages = {247-262},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/TurgutDurduran/TDurduran1999OEv4i8.pdf}
}
@article{DurduranYCB97,
author = {Durduran, T. and Yodh, A. G. and Chance, B. and Boas, D. A.},
title = {Does the photon-diffusion coefficient depend on absorption?},
journal = {Journal Of The Optical Society Of America A-Optics Image Science
And Vision},
year = {1997},
volume = {14},
pages = {3358-3365},
doi = {10.1364/JOSAA.14.003358},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/TurgutDurduran/TDurduran1997JOSAv14i12.pdf}
}
@article{DurduranYBDGWZY04,
author = {Durduran, T. and Yu, G. and Burnett, M. G. and Detre, J. A. and Greenberg,
J. H. and Wang, J. and Zhou, C. and Yodh, A. G.},
title = {Diffuse optical measurement of blood flow, blood oxygenation, and
metabolism in a human brain during sensorimotor cortex activation},
journal = {Optics Letters},
year = {2004},
volume = {29},
pages = {1766-1768},
doi = {10.1364/OL.29.001766},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/TurgutDurduran/turgutHumanOL2004.pdf}
}
@article{durduran:037004,
author = {Turgut Durduran and Chao Zhou and Erin M. Buckley and Meeri N. Kim
and Guoqiang Yu and Regine Choe and J. William Gaynor and Thomas
L. Spray and Suzanne M. Durning and Stefanie E. Mason and Lisa M.
Montenegro and Susan C. Nicolson and Robert A. Zimmerman and Mary
E. Putt and Jiongjiong Wang and Joel H. Greenberg and John A. Detre
and Arjun G. Yodh and Daniel J. Licht},
title = {Optical measurement of cerebral hemodynamics and oxygen metabolism
in neonates with congenital heart defects},
journal = {Journal of Biomedical Optics},
year = {2010},
volume = {15},
pages = {037004},
number = {3},
month = {May},
eid = {037004},
doi = {10.1117/1.3425884},
keywords = {biomedical MRI; biomedical optical imaging; haemodynamics; haemorheology;
infrared spectroscopy; molecular biophysics; neurophysiology; proteins},
numpages = {10},
publisher = {SPIE},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2010/durduran2010-jbo15-3.pdf}
}
@article{durduran2009-optexp17,
author = {Turgut Durduran and Chao Zhou and Brian L. Edlow and Guoqiang Yu
and Regine Choe and Meeri N. Kim and Brett L. Cucchiara and Mary
E. Putt and Qaisar Shah and Scott E. Kasner and Joel H. Greenberg
and Arjun G. Yodh and John A. Detre},
title = {Transcranial optical monitoring of cerebrovascular hemodynamics in
acute stroke patients},
journal = {Opt. Express},
year = {2009},
volume = {17},
pages = {3884--3902},
number = {5},
doi = {10.1364/OE.17.003884},
publisher = {OSA},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/durduran2009-optexp17.pdf}
}
@article{citeulike:7134761,
author = {Edlow, Brian L. and Kim, Meeri N. and Durduran, Turgut and Zhou,
Chao and Putt, Mary E. and Yodh, Arjun G. and Greenberg, Joel H.
and Detre, John A.},
title = {The effects of healthy aging on cerebral hemodynamic responses to
posture change},
journal = {Physiological Measurement},
year = {2010},
volume = {31},
pages = {477-495},
number = {4},
month = {April},
abstract = {Aging is associated with an increased incidence of orthostatic hypotension,
impairment of the baroreceptor reflex and lower baseline cerebral
blood flow. The effect of aging on cerebrovascular autoregulation,
however, remains to be fully elucidated. We used a novel optical
instrument to assess microvascular cerebral hemodynamics in the frontal
lobe cortex of 60 healthy subjects ranging from ages 20–78. Diffuse
correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS)
were used to measure relative cerebral blood flow (rCBF), total hemoglobin
concentration (THC), oxyhemoglobin concentration (HbO 2 ) and deoxyhemoglobin
concentration (Hb). Cerebral hemodynamics were monitored for 5 min
at each of the following postures: head-of-bed 30°, supine, standing
and supine. Supine-to-standing posture change caused significant
declines in rCBF, THC and HbO 2 , and an increase in Hb, across the
age continuum ( p < 0.01). Healthy aging did not alter postural changes
in frontal cortical rCBF ( p = 0.23) and was associated with a smaller
magnitude of decline in HbO 2 ( p < 0.05) during supine-to-standing
posture change. We conclude that healthy aging does not alter postural
changes in frontal cortical perfusion.},
day = {01},
doi = {10.1088/0967-3334/31/4/002},
issn = {0967-3334},
keywords = {aging, dcs, healthy, healthy\_aging, hob, nirs},
posted-at = {2010-05-07 17:07:03},
priority = {0},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2010/edlow2010-effects-of-healthy-aging.pdf}
}
@article{fisher2008tpe,
author = {Fisher, J A N and Barchi, J R and Welle, C G and Kim, G H and Kosterin,
P and Obaid, A L and Yodh, A G and Contreras, D and Salzberg, B M},
title = {Two-photon excitation of potentiometric probes enables optical recording
of action potentials from mammalian nerve terminals in situ},
journal = {Journal of Neurophysiology},
year = {2008},
pages = {00929--2007},
doi = {10.1152/jn.00929.2007},
publisher = {Am Physiological Soc},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/fisher2photon.pdf}
}
@article{FisherCCY04,
author = {Fisher, J. A. N. and Civillico, E. F. and Contreras, D. and Yodh,
A. G.},
title = {In vivo fluorescence microscopy of neuronal activity in three dimensions
by use of voltage-sensitive dyes},
journal = {Optics Letters},
year = {2004},
volume = {29},
pages = {71-73},
doi = {10.1364/OL.29.000071},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/JonathanFisher/JFisher2004OLv29i1.pdf}
}
@article{FisherMYR06,
author = {Fisher, J. A. N. and Marchenko, V. A. and Yodh, A. G. and Rogers,
R. F.},
title = {Spatiotemporal Activity Patterns During Respiratory Rhythmogenesis
in the Rat Ventrolateral Medulla},
journal = {J Neurophysiol},
year = {2006},
volume = {95},
pages = {1982-1991},
doi = {10.1152/jn.00674.2005},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/JonathanFisher/Fisher_etal_JNeurophys_2005.pdf}
}
@article{FisherSY05,
author = {Fisher, J. A. N. and Salzberg, B. M. and Yodh, A. G.},
title = {Near infrared two-photon excitation cross-sections of voltage-sensitive
dyes},
journal = {J Neurosci Methods},
year = {2005},
volume = {148},
pages = {94-102},
doi = {10.1016/j.jneumeth.2005.06.027},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/JonathanFisher/Fisher_etal_JNeurosciMeth_2005.pdf}
}
@article{fisher2009-jcp,
author = {Jonathan A. N. Fisher and Kimihiro Susumu and Michael J. Therien
and Arjun G. Yodh},
title = {One- and two-photon absorption of highly conjugated multiporphyrin
systems in the two-photon Soret transition region},
journal = {The Journal of Chemical Physics},
year = {2009},
volume = {130},
pages = {134506},
number = {13},
month = {April},
doi = {10.1063/1.3089795},
numpages = {8},
publisher = {AIP},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/JonathanFisher/fisher_etal_JCP2009.pdf}
}
@article{Goff201046,
author = {Donna A. Goff and Erin M. Buckley and Turgut Durduran and Jiongjong
Wang and Daniel J. Licht},
title = {Noninvasive Cerebral Perfusion Imaging in High-Risk Neonates},
journal = {Seminars in Perinatology},
year = {2010},
volume = {34},
pages = {46 - 56},
number = {1},
month = {February},
note = {Imaging the Developing Brain},
doi = {DOI:10.1053/j.semperi.2009.10.005},
issn = {0146-0005},
keywords = {infant cerebral blood flow},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2010/goff2010-noninvasive-cerebral.pdf}
}
@article{HolbokeTLSFKBCY00,
author = {Holboke, M. J. and Tromberg, B. J. and Li, X. and Shah, N. and Fishkin,
J. and Kidney, D. and Butler, J. and Chance, B. and Yodh, A. G.},
title = {Three-dimensional diffuse optical mammography with ultrasound localization
in a human subject},
journal = {Journal Of Biomedical Optics},
year = {2000},
volume = {5},
pages = {237-247},
doi = {10.1117/1.429992},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/MonicaHolboke/holbokeJBO2000.pdf}
}
@article{IntesRCNYC03,
author = {Intes, X. and Ripoll, J. and Chen, Y. and Nioka, S. and Yodh, A.
G. and Chance, B.},
title = {In vivo continuous-wave optical breast imaging enhanced with Indocyanine
Green},
journal = {Medical Physics},
year = {2003},
volume = {30},
pages = {1039-1047},
doi = {10.1118/1.1573791},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/XavierIntes/XIntes2003MPv30.pdf}
}
@article{citeulike:6170953,
author = {Kim, Meeri and Durduran, Turgut and Frangos, Suzanne and Edlow, Brian
and Buckley, Erin and Moss, Heather and Zhou, Chao and Yu, Guoqiang
and Choe, Regine and Maloney-Wilensky, Eileen and Wolf, Ronald and
Grady, M. and Greenberg, Joel and Levine, Joshua and Yodh, Arjun
and Detre, John and Kofke, W.},
title = {Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation
Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically
Brain-Injured Adults},
journal = {Neurocritical Care},
year = {2010},
volume = {12},
pages = {173-180},
number = {2},
month = {April},
abstract = {Abstract Background\ \ This study assesses the utility of
a hybrid optical instrument for noninvasive transcranial monitoring
in the neurointensive care unit. The instrument is based on diffuse
correlation spectroscopy (DCS) for measurement of cerebral blood
flow (CBF), and near-infrared spectroscopy (NIRS) for measurement
of oxy- and deoxy-hemoglobin concentration. DCS/NIRS measurements
of CBF and oxygenation from frontal lobes are compared with concurrent
xenon-enhanced computed tomography (XeCT) in patients during induced
blood pressure changes and carbon dioxide arterial partial pressure
variation. Methods\ \ Seven neurocritical care patients
were included in the study. Relative CBF measured by DCS (rCBFDCS),
and changes in oxy-hemoglobin (ΔHbO2), deoxy-hemoglobin (ΔHb), and
total hemoglobin concentration (ΔTHC), measured by NIRS, were continuously
monitored throughout XeCT during a baseline scan and a scan after
intervention. CBF from XeCT regions-of-interest (ROIs) under the
optical probes were used to calculate relative XeCT CBF (rCBFXeCT)
and were then compared to rCBFDCS. Spearman's rank coefficients were
employed to test for associations between rCBFDCS and rCBFXeCT, as
well as between rCBF from both modalities and NIRS parameters. Results\ \ rCBFDCS
and rCBFXeCT showed good correlation (r s\ =\ 0.73, P\ =\ 0.010)
across the patient cohort. Moderate correlations between rCBFDCS
and ΔHbO2/ΔTHC were also observed. Both NIRS and DCS distinguished
the effects of xenon inhalation on CBF, which varied among the patients.
Conclusions\ \ DCS measurements of CBF and NIRS measurements
of tissue blood oxygenation were successfully obtained in neurocritical
care patients. The potential for DCS to provide continuous, noninvasive
bedside monitoring for the purpose of CBF management and individualized
care is demonstrated.},
doi = {10.1007/s12028-009-9305-x},
keywords = {dcs, neurotrauma, nirs, validation, xenon},
priority = {0},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2010/kim2010-noninvasive-measurement.pdf}
}
@article{KoneckyOE2008,
author = {Konecky, S D and Panasyuk, G Y and Lee, K and Markel, V A and Yodh,
A G and Schotland, J C},
title = {Imaging complex structures with diffuse light},
journal = {Opt. Express},
year = {2008},
volume = {16},
pages = {5048-5060},
number = {7},
doi = {10.1364/OE.16.005048},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/KoneckyOE2008.pdf}
}
@article{sdkonecky2008MPv35,
author = {{Konecky}, S.~D. and {Choe}, R. and {Corlu}, A. and {Lee}, K. and
{Wiener}, R. and {Srinivas}, S.~M. and {Saffer}, J.~R. and {Freifelder},
R. and {Karp}, J.~S. and {Hajjioui}, N. and {Azar}, F. and {Yodh},
A.~G. },
title = {Comparison of diffuse optical tomography of human breast with whole-body
and breast-only positron emission tomography},
journal = {Medical Physics},
year = {2008},
volume = {35},
pages = {446-455},
number = {2},
month = {Feb},
doi = {10.1118/1.2826560},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/SDKonecky2008MPv35.pdf}
}
@article{xingdeAO1996,
author = {Li, X.D. and O'Leary, M.A. and Boas, D.A. and Chance, B. and Yodh,
A.G.},
title = {Fluorescent diffuse photon density waves in homogenous and heterogeneous
turbid media: analytic solutions and applications},
journal = {Applied Optics},
year = {1996},
volume = {35},
pages = {3746-3758},
doi = {10.1364/AO.35.003746},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/li1996-appl-optics.pdf}
}
@article{LiCY98,
author = {Li, X. D. and Chance, B. and Yodh, A. G.},
title = {Fluorescent heterogeneities in turbid media: limits for detection,
characterization, and comparison with absorption},
journal = {Applied Optics},
year = {1998},
volume = {37},
pages = {6833-6844},
doi = {10.1364/AO.37.006833},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/li1998-appl-optics.pdf}
}
@article{xingdefft1,
author = {Li, X. D. and Durduran, T. and Chance, B and Yodh, A. G. and Pattanayak,
D. N.},
title = {Diffraction tomography for biochemical imaging with diffuse-photon
density waves},
journal = {Optics Letters},
year = {1997},
volume = {22},
pages = {573-575},
number = {8},
doi = {10.1364/OL.22.000573},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/XingdeLi/Xli1997OLv22i8.pdf}
}
@article{xingdefft1errata,
author = {Li, X. D. and Durduran, T. and Chance, B and Yodh, A. G. and Pattanayak,
D. N.},
title = {Diffraction tomography for biochemical imaging with diffuse-photon
density waves: errata},
journal = {Optics Letters},
year = {1997},
volume = {22},
pages = {1198},
number = {15},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/XingdeLi/Xli1997OLv22i8errata.pdf}
}
@article{xingdefft2,
author = {Li, X. D. and Pattanayak, D. N. and Durduran, T. and Culver, J. P.
and Chance, B. and Yodh, A. G.},
title = {Near-field diffraction tomography with diffuse photon density waves},
journal = {Physical Review E},
year = {2000},
volume = {61},
pages = {4295-4309},
number = {4},
doi = {10.1103/PhysRevE.61.4295},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/li2000-phy-rev-e.pdf}
}
@article{sunargangzheng2007,
author = {Liping, S and Li, H and Sunar, U and Chen, J and Corbin, I and Yodh,
A G and Zheng, G},
title = {Naphthalocyanine-reconstituted LDL nanoparticles for in vivo cancer
imaging and treatment},
journal = {Int J of Nanomed},
year = {2007},
volume = {2},
pages = {767},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/sunarIJN_2417_Song.pdf}
}
@article{Luckl2010_FrontNeuroEg,
author = {Janos Luckl and Wesley Baker and Zheng-hui Sun and Turgut Durduran
and Arjun G Yodh and Joel H Greenberg},
title = {The biological effect of contralateral forepaw stimulation in rat
focal cerebral ischemia: a multispectral optical imaging study},
journal = {Frontiers in Neuroenergetics},
year = {2010},
volume = {2},
pages = {12},
number = {0},
abstract = {Our group has already published the possible neuroprotective effect
of contralateral forepaw stimulation in temporary focal ischemia
in a study. However, the background is still unclear. In the present
study we investigated the possible mechanism by monitoring focal
ischemia with multispectral (laser speckle, imaging of intrinsic
signals (OIS)) imaging. Sprague-Dawley rats were prepared using 1.2%
isoflurane anesthesia. The middle cerebral artery was occluded by
photothrombosis (4mW) and the common carotid artery was ligated permanently.
Physiological variables were constantly monitored during the experiment.
A 6x6 mm area centered 3 mm posterior and 4 mm lateral to Bregma
was thinned for laser speckle and OIS imaging. Nine circular regions-of-interests
(0.3 mm in diameter) were evenly spaced on the speckle contrast image
for the analysis of peri-infarct flow transients, blood flow and
metabolic changes. Both the sham (n=7) and forepaw stimulated animals
(n=7) underwent neurological examinations 24 h after ischemia at
which point all animals were sacrificed and the infarct size was
determined by triphenyltetrazolium chloride. The physiological variables
were in normal range and the experimental protocol did not cause
significant differences between groups. Both the neurological scores
(sham:3.6±1.7, stimulated:4.3±1.4,) and the infarct
volume (sham:124±39 mm3, stimulated: 147±47 mm3,) did
not show significant differences between groups. The forepaw stimulation
did not increase the intraischemic flow neither over the penumbral
or the peri-ischemic area. However, the hemoglobin transients related
metabolic load (CMRO2) was significantly lower (p<0.001) while
the averaged number of hyperemic flow transients were significantly
(p=0.013) higher in the forepaw (sham:3.5±2.2, stimulated:
7.0±2.3,) stimulated animals.},
doi = {10.3389/fnene.2010.00019},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2010/Luckl_Frontiers_in_Neuroenergetics_2010.pdf}
}
@article{luckl2008cpf,
author = {Luckl, J. and Zhou, C. and Durduran, T. and Yodh, A.G. and Greenberg,
J.H.},
title = {Characterization of periinfarct flow transients with laser speckle
and Doppler after middle cerebral artery occlusion in the rat},
journal = {Journal of Neuroscience Research},
year = {2009},
volume = {87},
pages = {1219-1229},
number = {5},
month = {April},
doi = {10.1002/jnr.21933},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/luckl2009-jnr-87-5.pdf}
}
@article{kalatumortnf,
author = {Menon, C and Polin, G. M. and Prabakaran, I. and Hs, A. and Cheung,
C and Culver, J. P. and Pingpank, J. F. and Sehgal, C. S. and Yodh,
A. G. and Buerk, D. G. and Fraker, D. L.},
title = {An Integrated Approach to Measuring Tumor Oxygen Status using Human
Melanoma Xenografts as a Model},
journal = {Cancer Research},
year = {2003},
volume = {63},
pages = {7232-7240},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/PDTrelated/CMenon2003CRv63.pdf}
}
@article{Mesquita2010HemodynamicAndMetabolic,
author = {Rickson C. Mesquita and Nicolas Skuli and Meeri N. Kim and Jiaming
Liang and Steve Schenkel and Amar J. Majmundar and M. Celeste Simon
and Arjun G. Yodh},
title = {Hemodynamic and metabolic diffuse optical monitoring in a mouse model
of hindlimb ischemia},
journal = {Biomed. Opt. Express},
year = {2010},
volume = {1},
pages = {1173--1187},
number = {4},
month = {Nov},
abstract = {Murine hindlimb ischemia is a useful model for investigation of the
mechanisms of peripheral arterial disease and for understanding the
role of endothelial cells and generic factors affecting vascular
regeneration or angiogenesis. To date, important research with these
models has explored tissue reperfusion following ischemia with Laser
Doppler methods, methods which provide information about superficial
(~mm) vascular regeneration. In this work, we employ diffuse correlation
spectroscopy (DCS) and diffuse optical spectroscopy (DOS) in mice
after hindlimb ischemia. We hypothesize that vascular re-growth is
not uniform in tissue, and therefore, since diffuse optical methods
are capable of probing deep tissues, that the diffuse optics approach
will provide a more complete picture of the angiogenesis process
throughout the whole depth profile of the limb. Besides increased
depth penetration, the combined measurements of DCS and DOS enable
all-optical, noninvasive, longitudinal monitoring of tissue perfusion
and oxygenation that reveals the interplay between these hemodynamic
parameters during angiogenesis. Control mice were found to reestablish
90\% of perfusion and oxygen consumption during this period, but
oxygen saturation in the limb only partially recovered to about 30\%
of its initial value. The vascular recovery of mice with endothelial
cell-specific deletion of HIF-2$\alpha$ was found to be significantly
impaired relative to control mice, indicating that HIF-2$\alpha$
is important for endothelial cell functions in angiogenesis. Comparison
of DOS/DCS measurements to parallel measurements in the murine models
using Laser Doppler Flowmetry reveal differences in the reperfusion
achieved by superficial versus deep tissue during neoangiogenesis;
findings from histological analysis of blood vessel development were
further correlated with these differences. In general, the combination
of DCS and DOS enables experimenters to obtain useful information
about oxygenation, metabolism, and perfusion throughout the limb.
The results establish diffuse optics as a practical noninvasive method
to evaluate the role of transcription factors, such as the endothelial
cell-specific HIF-2$\alpha$, in genetic ally modified mice.},
doi = {10.1364/BOE.1.001173},
keywords = {Biology; Light propagation in tissues; Medical and biological imaging;
Physiology},
publisher = {OSA},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2010/mesquita2010-hemodynamic-and-metabolic.pdf}
}
@inproceedings{mesquita2011_procfermi,
author = {Mesquita, R. C. and Yodh, A. G.},
title = {Diffuse optics: Fundamentals and tissue applications},
booktitle = {Proceedings of the International School of Physics "Enrico Fermi"
Course CLXXIII "Nano Optics and Atomics: Transport of Light and Matter
Waves},
year = {2011},
editor = {Kaiser, R. and Weirsma, D. S. and Fallini, L.},
volume = {173},
pages = {51-74},
doi = {10.3254/978-1-60750-755-0-51},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2011/Nano_Optics_and_Atomics_2011.pdf}
}
@article{NtziachristosCY99,
author = {Ntziachristos, V. and Chance, B. and Yodh, A. G.},
title = {Differential diffuse optical tomography},
journal = {Optics Express},
year = {1999},
volume = {5},
pages = {230-242},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/VasilisNtziachristos/VNtziachristos1999OEv5.pdf}
}
@article{NtziachristosHYC01,
author = {Ntziachristos, V. and Hielscher, A. H. and Yodh, A. G. and Chance,
B.},
title = {Diffuse optical tomography of highly heterogeneous media},
journal = {Ieee Transactions On Medical Imaging},
year = {2001},
volume = {20},
pages = {470-478},
doi = {10.1109/42.929613},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/VasilisNtziachristos/VNtziachristos2001IEEEMIv20i6.pdf}
}
@article{NtziachristosMYC99,
author = {Ntziachristos, V. and Ma, X. H. and Yodh, A. G. and Chance, B.},
title = {Multichannel photon counting instrument for spatially resolved near
infrared spectroscopy},
journal = {Review Of Scientific Instruments},
year = {1999},
volume = {70},
pages = {193-201},
doi = {10.1063/1.1149565},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/NtziachristosMYC99.pdf}
}
@article{NtziachristosYSC00,
author = {Ntziachristos, V. and Yodh, A. G. and Schnall, M. and Chance, B.},
title = {Concurrent MRI and diffuse optical tomography of breast after indocyanine
green enhancement},
journal = {Proceedings Of The National Academy Of Sciences Of The United States
Of America},
year = {2000},
volume = {97},
pages = {2767-2772},
doi = {10.1073/pnas.040570597},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/VasilisNtziachristos/VNtziachristos2000PNASv97i6.pdf}
}
@article{NtziachristosYSC02,
author = {Ntziachristos, V. and Yodh, A. G. and Schnall, M. D. and Chance,
B.},
title = {MRI-guided diffuse optical spectroscopy of malignant and benign breast
lesions},
journal = {Neoplasia},
year = {2002},
volume = {4},
pages = {347-354},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/VasilisNtziachristos/VNtziachristos2002Neov4.pdf}
}
@article{OlearyBCY95,
author = {Oleary, M. A. and Boas, D. A. and Chance, B. and Yodh, A. G.},
title = {Experimental images of heterogeneous turbid media by frequency-domain
diffusing-photon tomography},
journal = {Optics Letters},
year = {1995},
volume = {20},
pages = {426-428},
doi = {10.1364/OL.20.000426},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/oleary1995optlett20.pdf}
}
@article{OlearyBCY94,
author = {Oleary, M. A. and Boas, D. A. and Chance, B. and Yodh, A. G.},
title = {Reradiation and imaging of diffuse photon density waves using fluorescent
inhomogeneities},
journal = {Journal Of Luminescence},
year = {1994},
volume = {60-61},
pages = {281-286},
doi = {10.1016/0022-2313(94)90147-3},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/OlearyBCY94.pdf}
}
@article{OlearyBCY92,
author = {Oleary, M. A. and Boas, D. A. and Chance, B. and Yodh, A. G.},
title = {Refraction of diffuse photon density waves},
journal = {Physical Review Letters},
year = {1992},
volume = {69},
pages = {2658-2661},
doi = {10.1103/PhysRevLett.69.2658},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/oleary1992prl69.pdf}
}
@article{OLearyOL96,
author = {OLeary, M. A. and Boas, D. A. and Li, X. D. and Chance, B. and Yodh,
A. G.},
title = {Fluorescence lifetime imaging in turbid media},
journal = {Optics Letters},
year = {1996},
volume = {21},
pages = {158-160},
doi = {10.1364/OL.21.000158},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/oleary1996optlett21.pdf}
}
@article{PattanayakY99,
author = {Pattanayak, D. N. and Yodh, A. G.},
title = {Diffuse optical 3D slice imaging of bounded turbid media using a
new integro-differential equation},
journal = {Optics Express},
year = {1999},
volume = {4},
pages = {231-240},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/pattanayak1999-optics-express.pdf}
}
@article{RPeriniCMR08review,
author = {Perini, R and Choe, R and Yodh, A G and Sehgal, C and Divgi, C and
Rosen, M A},
title = {Non-invasive Assessment of Tumor Neovasculature: Techniques and Clinical
Applications},
journal = {Cancer and Metastasis Reviews},
year = {2008},
volume = {27},
pages = {615-630},
doi = {10.1007/s10555-008-9147-6},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/RPerini2008CMRv27.pdf}
}
@article{RipollNCPYN01,
author = {Ripoll, J. and Ntziachristos, V. and Culver, J. P. and Pattanayak,
D. N. and Yodh, A. G. and Nieto-Vesperinas, M.},
title = {Recovery of optical parameters in multiple-layered diffusive media:
theory and experiments},
journal = {Journal Of The Optical Society Of America A-Optics Image Science
And Vision},
year = {2001},
volume = {18},
pages = {821-830},
doi = {10.1364/JOSAA.18.000821},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/JorgeRipoll/JRipoll2001JOSAv18i4.pdf}
}
@article{Ross:2006:J-Surg-Res:16650871,
author = {Ross, H M and Smelstoys, J A and Davis, G J and Kapatkin, A S and
Del Piero, F and Reineke, E and Wang, H and Zhu, T C and Busch, T
M and Yodh, A G and Hahn, S M},
title = {Photodynamic therapy with motexafin lutetium for rectal cancer: a
preclinical model in the dog},
journal = {J Surg Res},
year = {2006},
volume = {135},
pages = {323-330},
number = {2},
month = {Oct},
abstract = {PURPOSE: Local recurrence of rectal cancer remains a significant clinical
problem despite multi-modality therapy. Photodynamic Therapy (PDT)
is a cancer treatment which generates tumor kill through the production
of singlet oxygen in cells containing a photosensitizing drug when
exposed to laser light of a specific wavelength. PDT is a promising
modality for prevention of local recurrence of rectal cancer for
several reasons: tumor cells may selectively retain photosensitizer
at higher levels than normal tissues, the pelvis after mesorectal
excision is a fixed space amenable to intra-operative illumination,
and PDT can generate toxicity in tissues up to 1 cm thick. This study
evaluated the safety, tissue penetration of 730 nm light, normal
tissue toxicity and surgical outcome in a dog model of rectal resection
after motexafin lutetium-mediated photodynamic therapy. METHODS:
Ten mixed breed dogs were used. Eight dogs underwent proctectomy
and low rectal end to end stapled anastomosis. Six dogs received
the photosensitizing agent motexafin lutetium (MLu, Pharmacyclics,
Inc., Sunnyvale, CA) of 2 mg/kg preoperatively and underwent subsequent
pelvic illumination of the transected distal rectum of 730 nm light
with light doses ranging from 0.5 J/cm(2) to 10 J/cm(2) three hours
after drug delivery. Two dogs received light, but no drug, and underwent
proctectomy and low-rectal stapled anastomosis. Two dogs underwent
midline laparotomy and pelvic illumination. Light penetration in
tissues was determined for small bowel, rectum, pelvic sidewall,
and skin. Clinical outcomes were recorded. Animals were sacrificed
at 14 days and histological evaluation was performed. RESULTS: All
dogs recovered uneventfully. No dog suffered an anastomotic leak.
Severe tissue toxicity was not seen. Histological findings at necropsy
revealed mild enteritis in all dogs. The excitation light penetration
depths were 0.46 +/- 0.18, 0.46 +/- 0.15, and 0.69 +/- 0.39 cm, respectively,
for rectum, small bowel, and peritoneum in dogs that had received
MLu. For control dogs without photosensitizer MLu, the optical penetration
depths were longer: 0.92 +/- 0.63, 0.67 +/- 0.10, and 1.1 +/- 0.80
cm for rectum, small bowel, and peritoneum, respectively. CONCLUSION:
Low rectal stapled anastomosis is safe when performed with MLu-mediated
pelvic PDT in a dog model. Significant tissue penetration of 730
nm light into the rectum and pelvic sidewall was revealed without
generation of significant toxicity or histological sequelae. Penetration
depths of 730 nm light in pelvic tissue suggest that microscopic
residual disease of less than 5 mm are likely to be treated adequately
with MLu-mediated PDT. This approach merits further investigation
as an adjuvant to total mesorectal excision and chemoradiation for
rectal cancer.},
doi = {10.1016/j.jss.2006.01.020},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/Hsing-WenWang/Ross:2006:J-Surg-Res:16650871.pdf}
}
@article{Shang2010MuscleFiber,
author = {Yu Shang and T. B. Symons and Turgut Durduran and A. G. Yodh and
Guoqiang Yu},
title = {Effects of muscle fiber motion on diffuse correlation spectroscopy
blood flow measurements during exercise},
journal = {Biomed. Opt. Express},
year = {2010},
volume = {1},
pages = {500--511},
number = {2},
month = {Sep},
abstract = {The influence of muscle fiber motion during exercise on diffuse correlation
spectroscopy (DCS) measurements of skeletal muscle blood flow is
explored. Isotonic (with muscle fiber motion) and isometric (without
muscle fiber motion) plantar flexion exercises were performed at
30\% of maximal force on a dynamometer, and muscle blood flow was
continuously monitored on the medial gastrocnemius (calf) muscle
of a healthy volunteer using DCS. During exercise, dynamometer recordings
including footplate position, footplate angular velocity, and plantar
flexion torque were obtained. Muscle fiber motions introduced artifacts
into the DCS signals, causing an overestimation of blood flow changes.
We show how proper co-registration of dynamometer recordings and
DCS measurements enables separation of the true blood flow responses
during exercise from those affected by the motion artifacts.},
doi = {10.1364/BOE.1.000500},
keywords = {Medical optics and biotechnology; Light propagation in tissues; Medical
and biological imaging; Spectroscopy, speckle},
publisher = {OSA},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2010/shang2010-effects-of-muscle-fiber-motion.pdf}
}
@article{SolonenkoCBKGVZWHY02,
author = {Solonenko, M. and Cheung, R. and Busch, T. M. and Kachur, A. and
Griffin, G. M. and Vulcan, T. and Zhu, T. C. and Wang, H. W. and
Hahn, S. M. and Yodh, A. G.},
title = {In vivo reflectance measurement of optical properties, blood oxygenation
and motexafin lutetium uptake in canine large bowels, kidneys and
prostates},
journal = {Physics In Medicine And Biology},
year = {2002},
volume = {47},
pages = {857-873},
doi = {10.1088/0031-9155/47/6/301},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/PDTrelated/MSolonenko2002PMBv47.pdf}
}
@article{ulasmouse2007,
author = {Sunar, U and Makonnen, S and Zhou, C and Durduran, T and Yu, Guoqiang
and Wang, H W and Lee, W M and Yodh, A G},
title = {Hemodynamic responses to antivascular therapy and ionizing radiation
assessed by diffuse optical spectroscopies},
journal = {Opt Expr},
year = {2007},
volume = {15},
pages = {15507-15516},
number = {23},
month = {November},
doi = {10.1364/OE.15.015507},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/UlasSunar/ulassunar2007optexpr.pdf}
}
@article{Sunar:2006:J-Biomed-Opt:17212544,
author = {Sunar, U and Quon, H and Durduran, T and Zhang, J and Du, J and Zhou,
C and Yu, G and Choe, R and Kilger, A and Lustig, R and Loevner,
L and Nioka, S and Chance, B and Yodh, A G},
title = {Noninvasive diffuse optical measurement of blood flow and blood oxygenation
for monitoring radiation therapy in patients with head and neck tumors:
a pilot study},
journal = {J Biomed Opt},
year = {2006},
volume = {11},
pages = {064021-064021},
number = {6},
month = {Nov-Dec},
abstract = {This pilot study explores the potential of noninvasive diffuse correlation
spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) for
monitoring early relative blood flow (rBF), tissue oxygen saturation
(StO(2)), and total hemoglobin concentration (THC) responses to chemo-radiation
therapy in patients with head and neck tumors. rBF, StO(2), and THC
in superficial neck tumor nodes of eight patients are measured before
and during the chemo-radiation therapy period. The weekly rBF, StO(2),
and THC kinetics exhibit different patterns for different individuals,
including significant early blood flow changes during the first two
weeks. Averaged blood flow increases (52.7+/-9.7)\% in the first
week and decreases (42.4+/-7.0)\% in the second week. Averaged StO(2)
increases from (62.9+/-3.4)\% baseline value to (70.4+/-3.2)\% at
the end of the second week, and averaged THC exhibits a continuous
decrease from pretreatment value of (80.7+/-7.0) [muM] to (73.3+/-8.3)
[muM] at the end of the second week and to (63.0+/-8.1) [muM] at
the end of the fourth week of therapy. These preliminary results
suggest daily diffuse-optics-based therapy monitoring is feasible
during the first two weeks and may have clinical promise.},
doi = {10.1117/1.2397548},
pmid = {17212544},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/UlasSunar/SUNAR_JBO064021.pdf}
}
@article{tromberg2008MPV2020,
author = {Bruce J. Tromberg and Brian W. Pogue and Keith D. Paulsen and Arjun
G. Yodh and David A. Boas and Albert E. Cerussi},
title = {Assessing the future of diffuse optical imaging technologies for
breast cancer management},
journal = {Medical Physics},
year = {2008},
volume = {35},
pages = {2443-2451},
number = {6},
doi = {10.1118/1.2919078},
publisher = {AAPM},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/BJTrombergMPvision2020.pdf}
}
@article{HwWangPESGYB,
author = {Wang, HW. and Putt, M. E. and Emanuele, M. J. and Shin, D. B. and
Glatstein, E. and Yodh, A. G. and Busch, T. M.},
title = {Treatment-Induced Changes in Tumor Oxygenation Predict Photodynamic
Therapy Outcome},
journal = {Cancer Research},
year = {2004},
volume = {64},
pages = {7553-7561},
doi = {10.1158/0008-5472.CAN-03-3632},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/Hsing-WenWang/hwWangCancerResrPDT04.pdf}
}
@article{HwWangZPSMDMFGHY,
author = {Wang, HW. and Zhu, T. C. and Putt, M. E. and Solonenko, M. and Metz,
J. and Dimofte, A. and Miles, J. and Fraker, D. L. and Glatstein,
E. and Hahn, S. M. and Yodh, A. G.},
title = {Broadband reflectance measurement of light penetration, blood oxygenation,
hemoglobin concentration, and drug concentration in humon intraperitoneal
tissues before and after photodynamic therapy},
journal = {Journal of Biomedical Optics},
year = {2005},
volume = {10},
pages = {014004-1-13},
doi = {10.1117/1.1854679},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/Hsing-WenWang/HW_Wang_JBO_2005_10_1_014004.pdf}
}
@article{Wang:2007:J-Biomed-Opt:17614731,
author = {Wang, H W and Finlay, J C and Lee, K and Zhu, T C and Putt, M E and
Glatstein, E and Koch, C J and Evans, S M and Hahn, S M and Busch,
T M and Yodh, A G},
title = {Quantitative comparison of tissue oxygen and motexafin lutetium uptake
by ex vivo and noninvasive in vivo techniques in patients with intraperitoneal
carcinomatosis},
journal = {J Biomed Opt},
year = {2007},
volume = {12},
pages = {034023-034023},
number = {3},
month = {May-Jun},
doi = {10.1117/1.2743082},
pmid = {17614731},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/Hsing-WenWang/hwwang2007jbo.pdf}
}
@article{Wang:2007:PhotoChemPhotoBiol,
author = {Wang, H W and Rickter, E and Yuan, M and Wileyto, E P and Glatstein,
E and Yodh, A G and Busch, T M},
title = {Effect of Photosensitizer Doser on Fluence Rate Responses to Photodynamic
Therapy},
journal = {Photochem Photobiol},
year = {2007},
volume = {83},
pages = {1-9},
doi = {10.1111/j.1751-1097.2007.00139.x},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/Hsing-WenWang/HWW_PhotochemPhotobiol_2007.pdf}
}
@article{YangLLC97,
author = {Yang, Y. and Liu, H. and Li, Xingde and Chance, B.},
title = {Low-cost frequency-domain photon migration instrument for tissue
spectroscopy, oximetry, and imaging},
journal = {Opt. Eng.},
year = {1997},
volume = {36},
pages = {1562-1569},
doi = {10.1117/1.601354},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/XingdeLi/YYang97OptEng36.pdf}
}
@book{Yodh_Boas_Rev,
title = {Functional Imaging with Diffusing Light},
publisher = {CRC Press},
year = {2003},
editor = {Tuan Vo-Dinh},
author = {A. G. Yodh and D. A. Boas},
pages = {21/1-45},
booktitle = {Biomedical Photonics Handbook},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/DavidBoas}
}
@article{YodhC95,
author = {{Yodh}, A. and {Chance}, B.},
title = {Spectroscopy and imaging with diffusing light},
journal = {Physics Today},
year = {1995},
volume = {48},
pages = {34-40},
month = {March},
doi = {10.1063/1.881445},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/yodhchancephysicstodayPTO000034.pdf}
}
@incollection{yu2011_ch10,
author = {Yu, G. and Durduran, T. and Zhou, C. and Cheng, R. and Yodh, A.G.},
title = {Near-Infrared Diffuse Correlation Spectroscopy for Assessment of
Tissue Blood Flow},
booktitle = {Handbook of Biomedical Optics},
publisher = {CRC Press: Boca Raton},
year = {2011},
editor = {Boas, D.A. and Pitris, C. and Ramanujam, N.},
pages = {195-216},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/2011/Handbook_Biomedical_Optics_chpt10.pdf}
}
@article{Yu:2006:Photochem-Photobiol:16696593,
author = {Yu, G and Durduran, T and Zhou, C and Zhu, T C and Finlay, J C and
Busch, T M and Malkowicz, S B and Hahn, S M and Yodh, A G},
title = {Real-time In Situ Monitoring of Human Prostate Photodynamic Therapy
with Diffuse Light},
journal = {Photochem Photobiol},
year = {2006},
volume = {82},
pages = {1279-84},
month = {Oct},
abstract = {Photodynamic therapy (PDT) requires oxygen to cause cellular and vascular
tumor damage. Tissue oxygen concentration, in turn, is influenced
by blood flow and blood oxygenation. Real- time clinical measurement
of these hemodynamic quantities, however, is rare. This paper reports
the development and application of a probe, combining diffuse reflectance
spectroscopy (DRS) for measurement of tumor blood oxygenation and
diffuse correlation spectroscopy (DCS) for measurement of tumor blood
flow. The instrument was adapted for clinical use during interstitial
prostate PDT. Three patients with locally recurrent prostate cancer
received 2 mg/kg motexafin lutetium (MLu) 3 hours before illumination
and a total light dose of 100 J/cm(2) at 150 mW/cm. Prostrate blood
oxygen saturation (StO2) decreased only slightly ( approximately
3\%) after treatment. On the other hand, prostate blood flow and
total hemoglobin concentration over the course of PDT decreased by
50\% and 15\%, respectively, suggesting MLu-mediated PDT has an anti-vascular
effect. While it is certainly impossible to draw definite conclusions
from measurements of only three patients, the observed differences
in tumor blood flow and blood oxygenation responses during PDT can,
in principle, be used to choose among tissue oxygen consumption models
and therefore emphasize the potential clinical value for simultaneous
monitoring of both parameters.},
doi = {10.1562/2005-10-19-RA-721},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/GuoqingYu/Yu:2006:Photochem-Photobiol:16696593.pdf}
}
@article{YuFDZWDY07,
author = {Yu, G. and Floyd, T. F. and Durduran, T. and Zhou, C. and Wang, J.
and Detre, J. A. and Yodh, A. G.},
title = {Validation of diffuse correlation spectroscopy for muscle blood flow
with concurrent arterial spin labeled perfusion MRI},
journal = {Optics Express},
year = {2007},
volume = {15},
pages = {1064-1075},
doi = {10.1364/OE.15.001064},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/GuoqingYu/YuFDZWDY07opticsExp.pdf}
}
@article{YuDFGY03,
author = {Yu, G. Q. and Durduran, T. and Furuya, D. and Greenberg, J. H. and
Yodh, A. G.},
title = {Frequency-domain multiplexing system for in vivo diffuse light measurements
of rapid cerebral hemodynamics},
journal = {Applied Optics},
year = {2003},
volume = {42},
pages = {2931-2939},
doi = {10.1364/AO.42.002931},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/GuoqingYu/GYAO2003.pdf}
}
@article{YuDLZCMY05,
author = {Yu, G. Q. and Durduran, T. and Lech, G. and Zhou, C. and Chance,
B. and Mohler, R. E. and Yodh, A. G.},
title = {Time-dependent blood flow and oxygenation in human skeletal muscles
measured with noninvasive near-infrared diffuse optical spectroscopies},
journal = {Journal of Biomedical Optics},
year = {2005},
volume = {10},
pages = {024027-1-12},
doi = {10.1117/1.1884603},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/GuoqingYu/Guoqiang-Muscle-Paper.pdf}
}
@article{YuDZWPSSGYB05,
author = {Yu, G. Q. and Durduran, T. and Zhou, C. and Wang, HW. and Putt, M.
E. and Saunders, H. M. and Sehgal, C. M. and Glatstein, E. and Yodh,
A. G. and Busch, T. M.},
title = {Noninvasive Monitoring of Murine Tumor Blood Flow During and After
Photodynamic Therapy Provides Early Assessment of Therapeutic Efficacy},
journal = {Clin Cancer Research},
year = {2005},
volume = {11},
pages = {3543-3552},
doi = {10.1158/1078-0432.CCR-04-2582},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/GuoqingYu/guoqiang-PDT.pdf}
}
@article{zhou2009JBO14,
author = {Chao Zhou and Stephanie A. Eucker and Turgut Durduran and Guoqiang
Yu and Jill Ralston and Stuart H. Friess and Rebecca N. Ichord and
Susan S. Margulies and Arjun G. Yodh},
title = {Diffuse optical monitoring of hemodynamic changes in piglet brain
with closed head injury},
journal = {Journal of Biomedical Optics},
year = {2009},
volume = {14},
pages = {034015},
number = {3},
doi = {10.1117/1.3146814},
numpages = {11},
publisher = {SPIE},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/ChaoZhou/Zhou_JBO_2009.pdf}
}
@article{chaojcbfmspeckle2008,
author = {Zhou, C and Shimazu, T and Durduran, T and Luckl, J and Kimberg,
D Y and Yu, G and Chen, X H and Detre, J A and Yodh, A G and Greenberg,
J H},
title = {Acute functional recovery of cerebral blood flow after forebrain
ischemia in rat},
journal = {J Cereb Blood Flow Metab},
year = {2008},
month = {April},
day = {02},
doi = {10.1038/jcbfm.2008.21},
publisher = {Nature Publishing Group},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/All/Zhou_JCBFM_AOP_2008.pdf}
}
@article{ChaoYFGYD06,
author = {Zhou, C. and Yu, G. and Daisuke, F. and Greenberg, J. H. and Yodh,
A. G. and Durduran, T.},
title = {Diffuse optical correlation tomography of cerebral blood flow during
cortical spreading depression in rat brain},
journal = {Optics Express},
year = {2006},
volume = {14},
pages = {1125-1144},
doi = {10.1364/OE.14.001125},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/ChaoZhou/CZdiffuseCorrTomogOptExp06.pdf}
}
@article{ZhuDNHY99,
author = {Zhu, Q. and Durduran, T. and Ntziachristos, V. and Holboke, M. and
Yodh, A. G.},
title = {Imager that combines near-infrared diffusive light and ultrasound},
journal = {Optics Letters},
year = {1999},
volume = {24},
pages = {1050-1052},
doi = {10.1364/OL.24.001050},
url = {http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/TurgutDurduran/QZhu1999OLv24i15.pdf}
}
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