ABSTRACT:
Non-invasive high-resolution biophotonics imaging technologies, such as optical coherence tomography (OCT), two-photon fluorescence (TPF) and second-harmonic generation (SHG) imaging, have emerged as a new imaging modality with a great translational potential for clinical applications, including detection of diseases at early stages, guidance of surgical interventions and monitoring of therapeutic effects. These technologies are capable of revealing structural, functional, and potentially molecular or biochemical information about biological tissues in real time with a resolution approaching conventional histology but without the need for tissue removal. Clinical translation of these high-resolution imaging technologies faces two critical challenges: (1) the need for enabling endomicroscopes/fiber-optic sensors that permit assessment of internal organs, and (2) the need for methods to enhance the limited intrinsic molecular contrast between normal and disease tissue. In this seminar, we will report on our recent research on developing ultrathin fiber-optic endomicroscopy technology, which is instrumental for translating OCT, TPF and SHG imaging into the clinic. We will also discuss our initial attempt to improve molecular sensitivity and specificity by development of innovative structured metallic and micellar nanoparticles which are potentially clinically translatable. In addition, we will present some exemplary applications of these biophotonic imaging technologies, including (1) assessment of normal and stimulated tissue regeneration processes, and (2) detection of abnormalities in the gastrointestinal tract (such as Barrett's, subsquamous Barrett's epithelium and cancer).
Biography: Xingde Li received his Ph.D. from the Department of Physics University of Pennsylvania in 1998. He joined the Ultrafast Optics Group at the Research Laboratory of Electronics of MIT as a Postdoctoral Research Associate, conducting research in the area of Biomedical Optics. He became an Assistant Professor at the Department of Bioengineering University of Washington in 2001, and is currently an Associate Professor and adjunct with Departments of EE, Physics, and Oral Biology. He has been serving as the chair of the Emerging Technologies Committee of the IEEE-Engineering in Medicine and Biology Society. Dr. Li received the Teacher/Mentor of the Year Award (UW Bioengineering) in 2002 and the NSF Career Award in 2004.
ABOUT:
These seminars are supported by the Biomedical Imaging and Spectroscopy Laboratory, the Center for Magnetic Resonance and Optical Imaging, the Department of Radiology and the Department of Physics & Astronomy at the University of Pennsylvania.
Organizers: Turgut Durduran and Arjun Yodh
For more information and other upcoming talks see: http://www.lrsm.upenn.edu/pmi/seminars/
Contact Turgut Durduran
durduran(at)sas(dot)upenn(dot)edu .