UPenn_MRSEC_2309043_IRG1_Janmey_Fibrin_Mechanoresponse_fig

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Five disk-shaped color images showing a circular fibrin gel viewed from below over forty minutes as the enzyme plasmin degrades it under shear strain that varies radially from zero percent at the center to seventy-five percent at the edge. At zero minutes the disk is uniformly blue, indicating intact polymerized gel. By thirty and forty minutes the outer ring of the disk has turned red, indicating degradation, while the center remains blue. A sixth panel is a line plot of turbidity degradation rate increasing roughly linearly with applied shear strain from one to nearly two between zero and seventy-five percent strain.

A circular fibrin gel viewed from below as plasmin degrades it under radially varying shear strain (zero at center, 75% at edge); the outer ring turns red (degraded) by 30–40 min while the strain-free center remains blue (intact). Panel f: turbidity decay rate rises roughly linearly with shear strain.