Stoney's British Pub
3007 Concord Pike
Perelman School of Medicine, University of Pennsylvania
“Snooze or Lose: The Impact of Genetics on Sleep Health”
Genome wide surveys in humans have identified genetic signals robustly associated with insomnia and other sleep-related traits, yet little is known about the functional roles of the underlying causal variants in regulating sleep duration or quality. Using a 3D Genomics approach, we identified a number of genes that regulate sleep. Our results provide the ﬁrst physical variant-to-gene mapping of human sleep genes followed by model organism-based prioritization, revealing novel and conserved processes in sleep regulation.